The science of skin longevity

The science behind GHK-Cu.

A copper-binding peptide with a remarkable role in skin biology. Explore the research on collagen, skin structure and visible skin quality.

Illustrative molecule rendered in clear icy-blue glass
What is GHK-Cu?

Three amino acids. One copper complex.

GHK is a small peptide made from three amino acids: glycine, histidine and lysine. It occurs naturally in the body and binds to copper to form GHK-Cu, the copper peptide studied for its role in skin health.

Why is it interesting for skin? Skin cells respond well to it in laboratory studies. Researchers have observed changes in collagen production, matrix components (the proteins and other molecules that form skin’s supporting framework), and enzymes involved in tissue remodelling. These processes help skin renew and maintain the structure that gives it strength and resilience.

See the laboratory research
How it works
From application to skin activity.

Start at the skin’s surface, then explore how GHK-Cu interacts with the cells that help maintain its structure.

Explore the research
GHK-Cu skincare routine by Koppā Beauty — serum, moisturizer and stick
01
Apply: the formula meets your skin

When you apply a formula, it spreads the copper peptide across your skin. The ingredients around it help hydrate, soften and condition the surface, while the formula influences how the peptide is released.

The serum spreads as a light fluid, the cream is massaged into skin, and the stick leaves a targeted layer of balm.

Copper peptides skincare by Koppā Beauty
02
Delivery: meeting the skin barrier

The skin barrier is its outer protective layer, also called the stratum corneum. How an ingredient moves beyond it depends on the formula and the condition of your skin.

Researchers measured copper passing through human skin after applying GHK-Cu in laboratory experiments. This showed that copper supplied by GHK-Cu could permeate the skin’s surface under the conditions studied. Some of that copper was also retained within the skin.

Illustrative molecule rendered in clear icy-blue glass
03
Cellular activity: supporting skin from within

Once it reaches the relevant skin cells, GHK-Cu can get to work. Fibroblasts are the cells that build and maintain skin’s supporting framework. In laboratory cultures, fibroblasts exposed to GHK-Cu produced more collagen, the protein that helps give skin its strength and structure.

In separate laboratory experiments, GHK-Cu increased production of selected glycosaminoglycans: long sugar molecules found between skin cells. These molecules help hold water and organise the surrounding framework, supporting the hydration and resilience of skin tissue.

Koppā GHK-Cu serum — 2% copper peptide serum for face
04
Why it matters for skin longevity

The evidence points to GHK-Cu supporting the skin matrix: the framework that helps keep skin strong and healthy. Laboratory studies show that it can stimulate collagen production and influence how this framework is renewed and maintained.

Supporting that structure is central to our approach to skin longevity. It is why we built the Koppā skincare line around GHK-Cu: to work with skin’s natural processes and help care for it over time.

Our formulas
Our products: GHK-Cu skincare in three forms.

Every Koppā formula is designed around GHK-Cu. A lightweight serum, a protective capsule cream and a waterless balm pair copper peptides with ingredients that hydrate, soften and support your skin.

Koppā GHK-Cu 2% High Potency Serum

Koppā Beauty — GHK-Cu copper peptides for skinTreat · 45 mL

GHK-Cu serum: peptide care + hydration

Lightweight copper-peptide care for smoother-looking, hydrated skin.

Ingredients and what they do for skin

GHK-Cu

GHK-Cu is a three-amino-acid peptide bound to copper. Research shows it can stimulate collagen production in skin cells. For skincare, the goal is a stronger-looking, smoother surface with improved firmness and a softer appearance of fine lines.

Glycerin + sodium hyaluronate

These water-binding ingredients draw moisture into the outer skin layer, helping skin feel plumper, smoother and less tight. Glycerin and sodium hyaluronate give the serum its refreshing hydration without a heavy finish.

Ceramides + panthenol

Ceramides help replenish the lipids that keep moisture in your skin. Panthenol adds hydration and soothing care, helping dry skin feel softer and more comfortable while supporting the protective barrier.

Designed around 2% GHK-Cu

Our serum brings 2% GHK-Cu into a lightweight water-based formula with supporting peptides. Moisture-binding ingredients and barrier care work alongside it, so daily peptide care also leaves skin feeling hydrated and comfortable.

Where it fits: After cleansing, before moisturiser.

Ingredient evidence +
Koppā GHK-Cu Advanced Capsule Cream

GHK-Cu copper peptide skin care from Koppā BeautyReplenish · 80 g

GHK-Cu capsule cream: protect + replenish

Protected copper-peptide capsules with rich hydration and barrier comfort.

Ingredients and what they do for skin

Glycerin + trehalose + hyaluronates

A blend of moisture-binding ingredients helps replenish water in the skin’s outer layer. Together, they ease the feeling of dehydration and leave skin looking plumper and feeling supple.

Squalane + jojoba oil

These skin-softening oils smooth dry, rough areas and help reduce moisture loss. They complement the cream’s water-binding ingredients for rich hydration, a softer surface and lasting comfort.

Encapsulated GHK-Cu + niacinamide

GHK-Cu sits inside visible blue capsules designed to help protect it until you massage the cream onto skin. Alongside it, 5% niacinamide supports the moisture barrier and a smoother, more even-looking complexion.

Protected in the cream. Released on skin.

The cream is built around 0.5% encapsulated GHK-Cu. Its blue capsules disperse as you massage, releasing the peptide into a moisturising base. Humectants add water-binding hydration while squalane and jojoba help keep skin soft and comfortable.

Where it fits: After lighter layers, before targeted balm.

Ingredient evidence +
Koppā GHK-Cu Face + Body Balm Stick

Koppā Beauty GHK-Cu copper peptide skincareTarget · 20 g

GHK-Cu balm stick: targeted peptide care

Copper peptides in a waterless balm for dry areas of the face and body.

Ingredients and what they do for skin

GHK-Cu

The stick contains 0.5% GHK-Cu, the copper peptide studied for collagen production and skin renewal. It brings peptide care to areas where you want smoother-looking skin and extra comfort, including the neck, chest and hands.

Waterless balm carrier

We place GHK-Cu in a water-free balm base chosen to support peptide stability and preserve its activity. The solid format glides directly over skin, leaving a conditioning layer exactly where you need it.

Jojoba, squalane + meadowfoam oils

These emollient oils soften rough patches, smooth the feel of dry skin and help seal in moisture. They give the stick a comfortable glide and a nourishing finish without a complicated application routine.

Built around GHK-Cu, made for on the go

The waterless carrier is part of the formula’s design around GHK-Cu. It combines copper peptides with nourishing oils in a portable stick, making targeted care easy to apply to the face, neck, hands, elbows and other dry areas.

Where it fits: After serum and moisturiser. In the morning, let it settle before SPF.

Ingredient evidence +
Formula comparison
Three formats. One copper-peptide approach.

Compare the concentration, supporting systems and routine role of each Koppā formula.

Each formula has a distinct job. Choose one starting point or use all three as a layered protocol.

Copper peptides skincare by Koppā Beauty
Published research
GHK-Cu skin research: the evidence behind our approach.

These studies are part of a wider body of research that informs our approach to GHK-Cu skincare. Scientists have explored its effects on collagen, skin structure and visible skin quality for decades. It may be new to your routine, but copper-peptide creams were already being studied in people in the 1990s. Explore the findings and original sources below.

01
Procollagen synthesis in human skin

20 volunteers overall · 10 used the copper-peptide cream · 1 month

Seven of the ten participants who used the copper-peptide cream showed increased procollagen synthesis in skin biopsies.

Study method & source +

Twenty volunteers applied paired study creams to their thighs for one month. Ten used the copper-peptide cream on one thigh and melatonin cream on the other; the remaining ten used vitamin C and tretinoin. Researchers compared skin biopsies before and after treatment.

Abdulghani et al. (1998). Disease Management and Clinical Outcomes, 1(4), 136–141.

Partly supported by Revlon Research Center and the UMDNJ Foundation.

Read the original study
02
Facial wrinkle measurements over eight weeks

40 women, ages 40–65 · Twice daily · 8 weeks

A GHK-Cu serum in a lipid-based nanocarrier improved measured wrinkle parameters compared with its control serum.

Study method & source +

The randomised, double-blind study compared the GHK-Cu formulation with its vehicle and a commercial Matrixyl 3000 product. It measured wrinkle volume and depth.

Badenhorst et al. (2016). Journal of Aging Science, 4:166.

Read the original study
03
Collagen synthesis in cultured fibroblasts

Laboratory experiment · Cultured cells

GHK-Cu stimulated collagen synthesis in fibroblast cultures, providing a basis for further research into the peptide.

Study method & source +

The researchers studied the tripeptide-copper complex in cultured fibroblasts. This work investigated biological activity under laboratory conditions.

Maquart et al. (1988). FEBS Letters, 238(2), 343–346.

Read the original study

Formula details

The thinking behind our formulas: GHK-Cu skincare.

Our expertise is in building the whole formula around GHK-Cu. We focus on the active level, how the peptide is protected in its chosen base, and the ingredients that help your skin feel good every day.

The active level, considered

The serum contains 2% GHK-Cu; the capsule cream and balm stick each contain 0.5%. Concentration is one part of the design, alongside the carrier and supporting ingredients.

The whole formula matters

Protecting the peptide’s activity is a formulation priority. We use a compatible water-based serum, visible protective capsules in the cream, and a waterless balm carrier in the stick. Each base is chosen around GHK-Cu and the way you use the product.

Naturally blue copper peptides

The blue comes from the copper-peptide complex itself. You can see it in the serum, the cream’s blue capsules and the balm. We do not add artificial blue colour: the appearance comes from what is inside the formula.

Discover our philosophy
Understanding GHK-Cu skincare.

A naturally occurring peptide. Decades of research. Clear answers for your daily skincare.

Blue copper-peptide powder beside a clear glass vial and laboratory dish
What is GHK-Cu?+

GHK-Cu is a copper peptide made from glycine, histidine and lysine, three amino acids bound to a copper ion. GHK occurs naturally in the body. In skincare, GHK-Cu is also listed as Copper Tripeptide-1 and is used in formulas designed to support smoother-looking, resilient skin.

Is GHK-Cu actually effective for skin?+

Research supports GHK-Cu’s potential for skin care. Laboratory studies show increased collagen production, and small human studies of copper-peptide formulas have reported changes in procollagen and visible wrinkles. Results depend on the finished formula and consistent use; these studies explain the ingredient’s promise rather than guaranteeing the same result from every product.

Which studies support GHK-Cu for skin?+

Maquart and colleagues reported increased collagen production in fibroblast cultures in 1988. A 1998 study by Abdulghani and colleagues found increased procollagen in seven of ten people using a copper-peptide cream. In 2016, Badenhorst and colleagues reported improved wrinkle measurements with a GHK-Cu nanocarrier serum. The research cards above link to the original studies.

What makes Koppā’s GHK-Cu skincare formulas effective?+

Our formulas combine GHK-Cu with ingredients that support hydration, softness and the skin barrier. The serum uses a lightweight hydrating base, the cream protects GHK-Cu in capsules that disperse during massage, and the stick uses a waterless balm carrier chosen to support stability. That complete formula is central to our approach to healthy-looking skin.

Why are GHK-Cu skincare products blue?+

GHK-Cu has a natural blue colour because copper is bound to the peptide. That is where the colour in Koppā’s serum, cream capsules and balm comes from, with no added artificial blue dye. The shade can vary with the concentration and base; colour alone does not measure a product’s potency.

How does GHK-Cu work on the skin?+

GHK-Cu interacts with cells involved in maintaining skin’s supporting framework. In laboratory studies, fibroblasts exposed to it produced more collagen and selected glycosaminoglycans, molecules that help organise tissue and hold water. These findings are why copper peptides are used in skincare focused on firmness, texture and skin resilience.

Is GHK-Cu a new skincare ingredient?+

GHK-Cu may be new to your routine, but the science goes back decades. Collagen research was published in the 1980s, and copper-peptide creams were studied in people in the 1990s. Researchers continue to explore its activity and how different formulas deliver it to skin.

What concentration of GHK-Cu is in Koppā products?+

Koppā’s serum contains 2% GHK-Cu. The capsule cream contains 0.5% encapsulated GHK-Cu, and the balm stick contains 0.5% GHK-Cu. A higher percentage does not tell the whole story: the base, supporting ingredients and how the product fits your skin also matter.

Why does Koppā encapsulate GHK-Cu in its cream?+

The visible blue capsules are designed to help protect the copper peptide within the cream before application. As you massage the cream into skin, the capsules disperse, releasing GHK-Cu into the moisturising base. Hydrating ingredients and skin-softening oils work alongside the peptide.

Why is Koppā’s GHK-Cu balm stick waterless?+

The water-free carrier is chosen to support GHK-Cu stability while creating a portable, targeted format. Jojoba oil, squalane and meadowfoam oil condition dry skin, and the balm leaves a protective-feeling layer where you apply it. It is designed for easy peptide care on the face and body.

Which Koppā GHK-Cu product should I choose?+

Choose the serum for lightweight peptide care and hydration, the capsule cream for replenishing moisture and barrier comfort, or the balm stick for targeted dry areas and on-the-go use. You can use them individually or layer serum, cream and then balm where needed. Keep the routine simple enough to use consistently.

Simple skincare. Considered formulas.
Browse the GHK-Cu skincare range.

Our idea is to keep skincare simple. Three specialised formulas, each with a clear purpose: peptide care, replenishing moisture and targeted comfort. Choose what your skin needs and build a consistent routine for healthy-looking skin.

Browse the range