The koppā buying guide

Copper Peptide Eye Creams of 2026: Seven Compared, and What the Evidence Shows

Seven eye creams that list a copper peptide, compared on what their labels state: which copper ingredient, where it sits in the list, whether a percentage is given, the retinoid or caffeine beside it, price per ml or g, shipping and returns. koppā makes copper peptide skincare but no eye cream, so none of our products is ranked here, and the links to other brands earn us nothing.

The koppā GHK-Cu Face + Body Balm Stick, a pale blue copper peptide balm. koppā does not make an eye cream.

A copper peptide eye cream is an eye-area product that lists GHK-Cu (Copper Tripeptide-1) or a related copper complex. In practice the copper is rarely the main active: of the seven we compared, only one states how much GHK-Cu it contains, and in most the copper peptide sits in the back half of the ingredient list, often beside a retinoid that is likely doing more of the work. We read every label, ingredient list, shipping page and returns policy on the seller's own site on 4 November 2026. No peer-reviewed trial of any GHK-Cu eye product exists, and we say what the research does and does not show.

Our picks

Summary of recommendations

Highest stated GHK-Cu: Dr. Loren Pickart GHK Luxe Eye Cream (2%)

Best budget retinoid-free option: COSRX Advanced Snail Peptide Eye Cream

Lowest price per gram, with retinol for beginners: Anua Retinol 0.1 Caffeine Revitalizing Eye Cream

Only brand reporting eye-area measurements: Medicube PDRN Pink Peptide Eye Cream

Copper with retinal, if it comes back in stock: Cell Fusion C Red Ultimate Eye Cream

Most generous returns and free shipping: Osmotics Blue Copper 5 PRIME Eye Cream

Stated retinol and caffeine levels, while stock lasts: Drunk Elephant A-Shaba Complex Retinol Eye Serum with Caffeine + Copper Peptides

Our top pick, 4 November 2026: Dr. Loren Pickart GHK Luxe Eye Cream

If you want copper peptide to be the active in your eye cream, this is the one we would choose, for experienced users only. It is the only eye cream we found that states a GHK-Cu dose: 2%, given as 300 mg in 15 ml, with Copper Tripeptide-1 11th of 24 ingredients, no retinoid and no fragrance listed. Its own directions say to start every other day, warn against sensitive skin and say to stop if skin looks "loose". If you are new to actives or your eyelids react easily, start with COSRX instead.

US$57 for 15 ml (US$3.80 per ml) at Platinum Skin Care; returns only factory-sealed, with a 15% refund fee.

Disclosure

Why you should trust us

koppā makes copper peptide skincare, but we do not make an eye cream, so no koppā product is ranked or scored on this page, and koppā wins none of the categories in our scorecard. No brand paid to be included, and the links to other brands earn us nothing.

We spend all our time on GHK-Cu, so we read these labels closely: every figure comes from the seller's own product, shipping and returns pages, read on the date stated, with the link beside it. Where a brand gives a result without saying how many people took part, or where we could not verify something, we say so. Our balm stick is the only koppā product with under-eye directions; we describe it, with its limits, in one separate section and at the end of the page.

Method

How we evaluated copper peptide eye creams

We chose seven eye-area products that list a copper peptide and that people searching for a copper peptide eye cream are most likely to find, and compared them on five criteria:

Copper: which copper ingredient is listed, where it sits, and whether a percentage is stated.

Formula: what else is doing the work, such as a retinoid, caffeine, adenosine or other peptides.

Evidence: has the brand reported a test of the finished product around the eye, and how?

Cost: price per ml or g, and US shipping.

Returns: can you send it back once opened, if it stings?

Copper · Advantage: Dr. Pickart

Only Dr. Pickart states a GHK-Cu dose (2%, 300 mg in 15 ml), and its Copper Tripeptide-1 is the earliest in any list here, 11th of 24, just before the preservative. Next earliest is Drunk Elephant's Bis(Tripeptide-1) Copper Acetate, 14th of 59. In COSRX it is 24th of 28, in Anua 24th of 76 and in Medicube 47th of 52. Cell Fusion C names copper tripeptide-1 in its copy but publishes no ingredient list.

Formula · Advantage: depends on the retinoid

Four of the seven contain a retinoid: Anua and Medicube (retinol), Drunk Elephant (retinol, stated 0.1%) and Cell Fusion C (retinal, per the brand). Dr. Pickart, COSRX and Osmotics list none. Acetyl Hexapeptide-8, the peptide with a placebo-controlled eye-area trial1, is in COSRX, Anua and Medicube; adenosine is in the same three.

Evidence · Advantage: none

No brand reports a controlled trial of its finished eye product. Medicube reports eye-area firmness +2.87% and moisture +22.5% after one week, without the number of people, method or control. Drunk Elephant reports 97% improvement after four weeks, and Osmotics a four-week consumer perception study, neither with a number of people. Dr. Pickart says "Clinical Proven" without naming a study.

US shipping / Returns
Seller US shipping Returns
Platinum Skin Care (Dr. Pickart)

Fee at checkout; no free-shipping threshold

30 days from delivery; factory-sealed only; refund less a 15% fee, or store credit with no fee; shipping not refunded

COSRX

Fee at checkout; free over US$50

30 days from delivery; unopened and unused

Ulta (Anua)

Free standard shipping over US$35

Not checked: Ulta's returns page was down for maintenance on 4 November 2026

Medicube US

US$6.99; free to the continental US over US$80

No change-of-mind returns; damaged or defective only

Cell Fusion C

US$6.99; free over US$50

14 days from receipt; unused, in original packaging

Osmotics

Free on all orders (5 to 7 business days)

30 days from order; the unused portion of an opened product accepted, not an empty one; shipping not refunded

Drunk Elephant

US$5.95; free over US$40

30 days from purchase; condition not stated on the page we read

Platinum Skin Care (Dr. Pickart)

US shipping

Fee at checkout; no free-shipping threshold

Returns

30 days from delivery; factory-sealed only; refund less a 15% fee, or store credit with no fee; shipping not refunded

COSRX

US shipping

Fee at checkout; free over US$50

Returns

30 days from delivery; unopened and unused

Ulta (Anua)

US shipping

Free standard shipping over US$35

Returns

Not checked: Ulta's returns page was down for maintenance on 4 November 2026

Medicube US

US shipping

US$6.99; free to the continental US over US$80

Returns

No change-of-mind returns; damaged or defective only

Cell Fusion C

US shipping

US$6.99; free over US$50

Returns

14 days from receipt; unused, in original packaging

Osmotics

US shipping

Free on all orders (5 to 7 business days)

Returns

30 days from order; the unused portion of an opened product accepted, not an empty one; shipping not refunded

Drunk Elephant

US shipping

US$5.95; free over US$40

Returns

30 days from purchase; condition not stated on the page we read

Compare the seven eye creams See the balm stick, $45

Shipping and returns read on each seller's own policy pages on 4 November 2026. Policies change, so check before you order. An eye product that stings is a common reason to return one, and only Osmotics accepts an opened product.

Cost · Advantage: Anua

Anua is the cheapest per unit: US$22 for 1.05 oz at Ulta, about US$0.74 per g if Ulta's ounce is a weight, which it does not say. COSRX costs US$1.12 per ml (US$28 for 25 ml) and Dr. Pickart US$3.80 per ml. Osmotics is the most expensive, US$8.11 per ml (US$120 for 14.79 ml). Medicube does not state its size on its US page.

Returns · Advantage: Osmotics

Osmotics takes back the unused portion of an opened product within 30 days, with free shipping on every order. Medicube accepts no change-of-mind returns, and Dr. Pickart's retailer takes only factory-sealed products, less a 15% fee.

The comparison

Seven copper peptide eye creams compared

Start with what bothers you around the eyes and whether you want a retinoid. Each card gives the reason to choose that product and the limits of what its label tells you.

Seven eye creams, one comparison

Scroll horizontally for all seven eye creams
Seven eye creams, one comparison
Eye cream Dr. Loren Pickart GHK Luxe Eye Cream Highest stated GHK-Cu COSRX Advanced Snail Peptide Eye Cream Best budget retinoid-free Anua Retinol 0.1 Caffeine Revitalizing Eye Cream Lowest price per gram Medicube PDRN Pink Peptide Eye Cream Only eye-area figures reported Cell Fusion C Red Ultimate Eye Cream Copper with retinal Osmotics Blue Copper 5 PRIME Eye Cream Best returns, free shipping Drunk Elephant A-Shaba Complex Retinol Eye Serum with Caffeine + Copper Peptides Being discontinued
Copper ingredient, as listed2% GHK-Cu (300 mg in 15 ml), statedCopper Tripeptide-1, 24th of 28; percentage not statedCopper Tripeptide-1, 24th of 76; percentage not statedCopper Tripeptide-1, 47th of 52; percentage not statedCopper Tripeptide-1, named in the brand's copy; ingredient list not publishedPrezatide Copper Acetate (a GHK-Cu salt) 22nd of 29, plus Copper PCA; percentage not statedBis(Tripeptide-1) Copper Acetate 14th of 59, plus Copper Lysinate/Prolinate; copper percentage not stated
Size15 ml (1/2 oz)25 ml1.05 ozNot stated on the US page15 ml0.5 fl oz (14.79 ml)15 ml
List priceUS$57US$28US$22US$26US$27US$120US$65
Price per ml or gUS$3.80 per mlUS$1.12 per mlAbout US$0.74 per gCannot be calculatedUS$1.80 per mlUS$8.11 per mlUS$4.33 per ml
GHK-Cu percentage stated2%Not statedNot statedNot statedNot statedNot statedNot stated
Retinoid in the ingredient listNoNoRetinol (0.1% in the name)RetinolRetinal, per the brandNoRetinol, stated 0.1%
No fragrance in the ingredient listNo ingredient list published
Eye-area test of the finished product reportedClaimed ("Clinical Proven"); no study namedNone reportedNone reportedYes: 1 week; number of people not statedNone reportedConsumer perception only, 4 weeks; number not statedYes: 4 weeks; number of people not stated
Shop

One-time US list prices on each brand's own site (Ulta for Anua; Platinum Skin Care, an authorised retailer, for Dr. Pickart), checked 4 November 2026, before promotions, tax and delivery. Grams and millilitres are different units, so we compare them only within a unit. A percentage that is not stated is not evidence a formula contains none. No koppā product is in this comparison.

Category by category

The full scorecard: which eye cream wins each category?

Eleven categories. koppā is not in the running: we make no eye cream.

Winner / Why
Category Winner Why
Highest stated GHK-Cu

Dr. Pickart GHK Luxe, 2%

300 mg in 15 ml is 20 mg per ml, or 2%. No other eye product here states a copper percentage.

Earliest copper in the ingredient list

Dr. Pickart, 11th of 24

Next: Drunk Elephant 14th of 59 (a different GHK salt), COSRX 24th of 28, Anua 24th of 76, Medicube 47th of 52.

Lowest price per ml or g

Anua, about US$0.74 per g

US$22 for 1.05 oz, assuming weight. COSRX is US$1.12 per ml.

Largest size

Anua, 1.05 oz (about 30 g)

COSRX 25 ml; the others 15 ml, 14.79 ml or not stated.

Retinoid-free with GHK-Cu

COSRX (cheapest) and Dr. Pickart (highest dose)

Anua, Medicube, Cell Fusion C and Drunk Elephant all contain a retinoid. Osmotics is also retinoid-free but states no copper percentage.

Copper with a retinoid, on a budget

Anua, US$22

Retinol in the name at 0.1%. Cell Fusion C (retinal, US$27) was sold out.

Eye-area testing reported

Medicube

Firmness +2.87% and moisture +22.5% after one week; number of people and method not stated. Nobody reports a controlled test of a finished product.

Most generous returns

Osmotics

The unused portion of an opened product within 30 days. Medicube takes no change-of-mind returns; the Dr. Pickart retailer takes sealed products only, less 15%.

Free shipping, lowest threshold

Osmotics, all orders

Then Ulta (US$35) and Drunk Elephant (US$40).

Most expensive per ml

Osmotics, US$8.11 per ml

US$120 for 14.79 ml.

Fragrance-free

Drunk Elephant, stated

It claims fragrance-free outright. The other five that publish an ingredient list list no fragrance; Cell Fusion C publishes no list.

Highest stated GHK-Cu

Winner

Dr. Pickart GHK Luxe, 2%

Why

300 mg in 15 ml is 20 mg per ml, or 2%. No other eye product here states a copper percentage.

Earliest copper in the ingredient list

Winner

Dr. Pickart, 11th of 24

Why

Next: Drunk Elephant 14th of 59 (a different GHK salt), COSRX 24th of 28, Anua 24th of 76, Medicube 47th of 52.

Lowest price per ml or g

Winner

Anua, about US$0.74 per g

Why

US$22 for 1.05 oz, assuming weight. COSRX is US$1.12 per ml.

Largest size

Winner

Anua, 1.05 oz (about 30 g)

Why

COSRX 25 ml; the others 15 ml, 14.79 ml or not stated.

Retinoid-free with GHK-Cu

Winner

COSRX (cheapest) and Dr. Pickart (highest dose)

Why

Anua, Medicube, Cell Fusion C and Drunk Elephant all contain a retinoid. Osmotics is also retinoid-free but states no copper percentage.

Copper with a retinoid, on a budget

Winner

Anua, US$22

Why

Retinol in the name at 0.1%. Cell Fusion C (retinal, US$27) was sold out.

Eye-area testing reported

Winner

Medicube

Why

Firmness +2.87% and moisture +22.5% after one week; number of people and method not stated. Nobody reports a controlled test of a finished product.

Most generous returns

Winner

Osmotics

Why

The unused portion of an opened product within 30 days. Medicube takes no change-of-mind returns; the Dr. Pickart retailer takes sealed products only, less 15%.

Free shipping, lowest threshold

Winner

Osmotics, all orders

Why

Then Ulta (US$35) and Drunk Elephant (US$40).

Most expensive per ml

Winner

Osmotics, US$8.11 per ml

Why

US$120 for 14.79 ml.

Fragrance-free

Winner

Drunk Elephant, stated

Why

It claims fragrance-free outright. The other five that publish an ingredient list list no fragrance; Cell Fusion C publishes no list.

Compare the seven eye creams See the balm stick, $45
The products

The seven, with pros and cons

Prices are list prices before promotions on the seller's own site, checked 4 November 2026.

  1. 01
    Highest stated GHK-Cu

    Dr. Loren PickartGHK Luxe Eye Cream

    Copper ingredient, as listed
    2% GHK-Cu (300 mg in 15 ml), stated
    Size
    15 ml (1/2 oz)
    List price
    US$57
    Best for
    Experienced copper peptide users who want a known, high GHK-Cu dose around the eye and will build up slowly

    Our verdict This is the one we would choose if copper peptide is the point. Choose COSRX instead if your skin is sensitive or you are new to actives: the brand itself advises against sensitive skin.

    A 24-ingredient cream: water, ethylhexyl palmitate, squalane and cetyl alcohol, then dimethyl MEA (DMAE), an algae extract and pullulan, with Copper Tripeptide-1 11th, immediately before phenoxyethanol, a preservative normally used at 1% or less, which is consistent with the stated 2%. CoQ10, tocotrienols, lutein, allantoin and aloe complete it. The directions are unusually cautious: apply a very thin layer, use every other day and build tolerance, stop for a week if irritation starts, do not use at the same time as an acid serum or cream, and stop for a few days "if you notice things are looking loose". The brand says it "has been proven to smooth and refine" eye-area skin but names no study, number of people or duration.

    Pros

    • The only eye cream here stating a GHK-Cu dose: 2%
    • Copper Tripeptide-1 11th of 24, the earliest in any list
    • No retinoid and no fragrance in the ingredient list
    • Short ingredient list

    Cons and things to know

    • US$57 for 15 ml at platinumskincare.com, 4 November 2026; VIP price US$45.60 for logged-in members
    • The brand warns of irritation and "loose" skin with overuse, and advises against sensitive skin types
    • Efficacy claim not backed by a named study
    • Sold through a retailer: no free-shipping threshold; returns factory-sealed only, refund less a 15% fee
    • We read it at an authorised retailer because the Dr. Pickart brand site did not present a valid certificate
    platinumskincare.com
  2. 02
    Best budget retinoid-free

    COSRXAdvanced Snail Peptide Eye Cream

    Copper ingredient, as listed
    Copper Tripeptide-1, 24th of 28; percentage not stated
    Size
    25 ml
    List price
    US$28
    Best for
    A cheap, retinoid-free, fragrance-free eye cream that puts hydration first

    Our verdict Choose it if you want a gentle, low-cost start with no retinoid; the copper peptide is a minor ingredient and no percentage is given.

    Snail secretion filtrate leads the list (stated at 73.6%), then butylene glycol, glycerin, sunflower seed oil and niacinamide. Copper Tripeptide-1 is 24th of 28, alongside four other peptides: Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. Adenosine, panthenol and sodium hyaluronate are also listed. No fragrance, silicone or retinoid appears in the list, though the brand does not claim any of those. Directions: apply around the eyes after serum, massage and tap gently.

    Pros

    • US$1.12 per ml, the second-lowest here
    • Short, fragrance-free and retinoid-free ingredient list
    • Acetyl Hexapeptide-8 and adenosine, both tested around the eye12
    • Free US shipping over US$50

    Cons and things to know

    • US$28 for 25 ml on cosrx.com, 4 November 2026; backordered
    • Copper Tripeptide-1 near the end of the list, no percentage
    • Contains snail filtrate, so not vegan
    • No test of the finished product reported
    • Returns unopened and unused only, within 30 days
    cosrx.com
  3. 03
    Lowest price per gram

    AnuaRetinol 0.1 Caffeine Revitalizing Eye Cream

    Copper ingredient, as listed
    Copper Tripeptide-1, 24th of 76; percentage not stated
    Size
    1.05 oz
    List price
    US$22
    Best for
    First-time retinol users who want an all-in-one eye cream at a low price

    Our verdict Choose it if you want retinol, caffeine and ceramides for the least money and are willing to start slowly; copper is one of four peptides in a long list.

    A 76-ingredient cream sold only at Ulta: water, propanediol, dipropylene glycol, niacinamide and glycerin, then meadowfoam seed oil, a cyclic silicone (cyclohexasiloxane, 8th), caffeine, panthenol, collagen, squalane and adenosine. Six ceramides follow, then four peptides: Hexapeptide-2, Copper Tripeptide-1 (24th), Acetyl Hexapeptide-8 and Acetyl Dipeptide-1 Cetyl Ester, with retinol 27th and ten forms of hyaluronic acid after it. No fragrance is listed. Directions: dot around the eye area after cleansing; if new to retinol, start every other day and patch test first. The per-gram figure assumes Ulta's 1.05 oz is a weight, which the page does not say.

    Pros

    • About US$0.74 per g, the lowest here, and the largest size
    • Retinol, caffeine, six ceramides and adenosine together
    • Acetyl Hexapeptide-8, the peptide with a placebo-controlled eye-area trial1
    • Free standard shipping from Ulta over US$35

    Cons and things to know

    • US$22 for 1.05 oz at ulta.com, 4 November 2026; US$20.90 on Replenish & Save
    • Retinol near the eye needs a slow start
    • Contains a cyclic silicone
    • No test of the finished product reported
    • Ulta's returns terms could not be read on the check date
    ulta.com
  4. 04
    Only eye-area figures reported

    MedicubePDRN Pink Peptide Eye Cream

    Copper ingredient, as listed
    Copper Tripeptide-1, 47th of 52; percentage not stated
    Size
    Not stated on the US page
    List price
    US$26
    Best for
    Buyers already using the Medicube PDRN range who want retinol and caffeine in an eye step

    Our verdict Choose it if you already use Medicube and accept retinol and no returns; the copper peptide is fifth from last.

    Water, glycerin, dipropylene glycol, niacinamide and caprylic/capric triglyceride lead a 52-ingredient list that includes sodium DNA (the brand's salmon PDRN), vinyl dimethicone (a silicone, 17th), adenosine, retinol, caffeine and coffee seed extract. Copper Tripeptide-1 is 47th, followed by Acetyl Hexapeptide-8 and three palmitoyl peptides. No fragrance is listed. The brand reports eye-area firmness up 2.87% and moisture up 22.5% after one week, tested by "Global Institute of Dermatological Sciences", without the number of people, method or a control. Its FAQ advises starting gradually if you are new to retinol or have sensitive skin.

    Pros

    • The only brand reporting eye-area measurements of its finished product
    • Retinol, caffeine, PDRN and five peptides
    • Low price, US$26

    Cons and things to know

    • US$26 on medicube.us, 4 November 2026 (compare-at US$28); size not stated, so no per-ml price
    • Copper Tripeptide-1 47th of 52
    • Contains retinol and a silicone
    • The reported firmness change is small (2.87%), over one week, with no group size
    • No change-of-mind returns; free shipping only over US$80
    medicube.us
  5. 05
    Copper with retinal

    Cell Fusion CRed Ultimate Eye Cream

    Copper ingredient, as listed
    Copper Tripeptide-1, named in the brand's copy; ingredient list not published
    Size
    15 ml
    List price
    US$27
    Best for
    Retinal users who want two named peptides in a small tube, if it returns to stock

    Our verdict Choose it only once it is back in stock and publishes its ingredient list; until then we cannot check where the copper sits.

    The brand names "Retinal and Dual Peptides (Acetyl Tetrapeptide-5 & Copper Tripeptide-1)", with Jeju camellia, raspberry seed oil and a "Red Active Complex". The product page publishes no ingredient list, so the copper peptide's position, and anything else in the formula, are not stated on the brand's page. It says the cream is also "effective on frown lines, smile lines, neck lines, and jawline", without a test. A small 15 ml tube suits a retinoid eye product.

    Pros

    • Retinal plus two named peptides
    • US$1.80 per ml at list price (US$1.33 on the sale price of US$20)
    • Free US shipping over US$50

    Cons and things to know

    • US$27 on cellfusionc.com, 4 November 2026; listed as sold out
    • No ingredient list on the product page
    • No directions beyond the areas it can be used on
    • No test of the finished product reported
    • Returns within 14 days, unused, in original packaging
    cellfusionc.com
  6. 06
    Best returns, free shipping

    OsmoticsBlue Copper 5 PRIME Eye Cream

    Copper ingredient, as listed
    Prezatide Copper Acetate (a GHK-Cu salt) 22nd of 29, plus Copper PCA; percentage not stated
    Size
    0.5 fl oz (14.79 ml)
    List price
    US$120
    Best for
    Hooded upper lids and crow's feet, for someone who wants a returnable trial

    Our verdict Choose it if being able to return an opened eye cream matters more than price; it is the most expensive per ml here and its evidence is self-reported.

    A 29-ingredient cream of water, squalane, cetyl alcohol and two silicones (dimethicone and dimethiconol), with Matrixyl 3000 (Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7), Acetyl Tetrapeptide-2, albizia bark extract and darutoside. The copper is listed as Prezatide Copper Acetate, the drug name for GHK-Cu acetate, 22nd, with Copper PCA, a different copper compound, 21st. Mica and titanium dioxide give an optical brightening effect. Its "94% firmer lids" and similar figures come from a four-week consumer perception study with no number stated; its instrumental figures are, in the brand's words, the supplier's data on individual ingredients, not this cream. Directions: a rice-grain amount per eye, tapped along the orbital bone, morning and evening.

    Pros

    • The only seller here accepting the unused portion of an opened product, within 30 days
    • Free US shipping on every order
    • Peptide-dense formula with eyelid-specific actives
    • No retinoid and no fragrance in the ingredient list

    Cons and things to know

    • US$120 for 0.5 fl oz on osmotics.com, 4 November 2026; US$8.11 per ml, the highest here
    • Copper listed late (22nd of 29), no percentage
    • Contains dimethicone and dimethiconol
    • Finished-product evidence is self-perception only
    osmotics.com
  7. 07
    Being discontinued

    Drunk ElephantA-Shaba Complex Retinol Eye Serum with Caffeine + Copper Peptides

    Copper ingredient, as listed
    Bis(Tripeptide-1) Copper Acetate 14th of 59, plus Copper Lysinate/Prolinate; copper percentage not stated
    Size
    15 ml
    List price
    US$65
    Best for
    Stated retinol (0.1%) and caffeine (3%) levels with a GHK copper salt listed early, while any stock lasts

    Our verdict Choose it only if you find it in stock: the formula is clearly described, but the brand is discontinuing it.

    States 0.1% retinol and 3% caffeine. Its copper is Bis(Tripeptide-1) Copper Acetate, a GHK-copper complex, 14th of 59, with Copper Lysinate/Prolinate, a different copper compound, 20th. The brand's key-ingredient copy calls it "Copper tripeptide-1", a name that does not appear in its ingredient list. Niacinamide, boron nitride, sea buckthorn oil, mango seed butter and ceramide NP are also listed. It claims to be free of essential oils, silicones, fragrance, dyes and solvent alcohols. It reports 97% improvement in undereye bags, crow's feet and dark circles after four weeks, without a group size. Directions: pat one pump under and around the eyes, along the orbital bone, morning or night, with broad-spectrum sunscreen.

    Pros

    • Retinol and caffeine percentages stated
    • GHK copper salt relatively early, 14th of 59
    • Fragrance-free and silicone-free, per the brand
    • US$45.50 at 30% off, while shown

    Cons and things to know

    • US$65 list on drunkelephant.com, 4 November 2026; out of stock, with a "last chance" banner
    • Being discontinued
    • Copy and ingredient list name the copper differently
    • Test results given without the number of people
    • Return condition not stated on the page we read
    drunkelephant.com
Check the label

Sold as copper peptide eye creams, but not GHK-Cu

Not every eye cream marketed with copper peptides contains GHK-Cu. We left these out, checked on 4 November 2026:

Osmotics Under Eye Rejuvenator. Its own page calls it "a copper peptide eye cream", but its published ingredient list (27 items) contains no copper ingredient at all.

Allies of Skin Peptides & Omegas Firming Eye Cream (US$85). Its copper is Copper Lysinate/Prolinate, 31st of 56, a different copper compound from GHK-Cu, so the GHK-Cu research does not apply to it.

SKIN functional Copper Tripeptide Eye Cream. A South African brand priced in rand that the brand does not sell to the US.

Ageless Humans Radium NAD+ & GHK cream (US$59.99). Marketed for dark circles, but the page gives no ingredient list or size.

CopperTheory GHK-Cu Under Eye Recovery Mask. Patches, not a cream, sold in Australian dollars; not checked further.

The names to look for are Copper Tripeptide-1, Prezatide Copper Acetate and Bis(Tripeptide-1) Copper Acetate, which are all GHK-copper complexes. Copper Lysinate/Prolinate and Copper PCA are different copper compounds. We compare face serums in our copper peptide serum guide.

Eyelid skin

Is the skin around the eyes really thinner?

Yes. The upper eyelid is the thinnest skin on the face in every study that has measured it. In three cadavers measured at 15 facial sites, the upper eyelid was thinnest in all three, with the nasal tip 3.30 times and the brow 2.8 times thicker3. In 10 cadaver heads sampled at 39 sites, the thinnest dermis was the upper inner eyelid at 758.9 µm, against 1,969.2 µm on the lower side of the nose4. In living people, a 2025 high-frequency ultrasound study of 45 adults aged 22 to 73 at 38 sites found a median upper-eyelid thickness of 573.5 µm, against 1,907 µm at the nasal tip5.

The skin under the eye also behaves differently with age. In a 1999 ultrasound study of 40 women at 12 facial sites, skin thickened with age everywhere except the infraorbital regions, the skin below the eyes6.

Thinner skin is plausibly easier for an ingredient to cross, and more easily irritated, but no study has measured GHK-Cu passing through eyelid skin. The skin-sample study of GHK-Cu used dermatomed skin from elsewhere: copper from a 0.68% water-based solution permeated it over 48 hours7.

Know what you are treating

What causes dark circles, puffiness and crow's feet, and which can a cream change?

These are three different problems with different causes, and a cream can reach only some of them.

Dark circles: several causes, often at once

Dark circles come from deep facial anatomy, soft-tissue changes including lower-eyelid bags, and skin factors8. A review lists genetics, excess pigment, pigment left after eczema or allergic contact dermatitis, swelling, visible blood vessels and shadowing from laxity or the tear trough, and notes "very little scientific data"9. In a 2026 observational study of 42 people, most had more than one type (pigmented, vascular and shadow); pigmented and shadow types were commoner in darker skin types and vascular in lighter ones10. That study was funded by AbbVie and was descriptive only.

What a cream can and cannot do for dark circles

A cream cannot change shadow from bone structure, fat or the tear trough89. Pigmented circles are mostly treated with ingredients borrowed from melasma, and copper peptides are not depigmenting9. For bluish, vascular circles, an open-label study of 57 people using 2% vitamin K with 0.1% retinol and vitamins C and E for 8 weeks reduced the vascular darkness in 47% but did not clearly remove pigmentation11. No copper peptide eye product reports a controlled dark-circle result.

Puffiness: mostly anatomy

Bags caused by fat pushing forward under the lower eyelid are a structural change8, and no cream changes anatomy; the options there are fillers or surgery. Caffeine is the usual cream ingredient for puffiness, and its eye-area data come from an uncontrolled, manufacturer-funded study: 40 people (37 completed) using an eye cream with vitamin C, peptides, chrysin and caffeine for 12 weeks showed improved dark circles on instrument measures12.

Crow's feet: the most treatable by cream

Crow's feet are lines formed by the muscle that closes the eye, deepened by sun damage. They are where eye-area cream trials have shown the clearest change: a peptide that relaxes muscle signalling beat placebo over 4 weeks1, and a peptide eye cream and face creams improved crow's-feet smoothness in 4-week split-face trials13. Daily sunscreen, retinoids and, medically, neuromodulator injections are the other routes.

The evidence

Is there evidence that copper peptide eye creams work?

Very little, and none of it peer reviewed. We say what kind of study each one is.

One eye-cream study, known only from a review

A 2002 study reported that a GHK-Cu eye cream used for 12 weeks by 41 women with mild to advanced sun damage improved lines and wrinkles, overall appearance, skin density and thickness more than both a placebo and a vitamin K eye cream. We know it only from a 2015 review by GHK's discoverer, who sells GHK products; the review cites it as an unpublished 2002 University of Pennsylvania report14. It is not on PubMed, we could not find its text, and its GHK-Cu concentration and sponsor are not reported. We describe it as reported, not as established.

No peer-reviewed GHK-Cu eye trial

Searches of PubMed for copper peptide eye cream and GHK-Cu periorbital studies found no peer-reviewed trial of any GHK-Cu eye product. None of the seven brands here reports a controlled test of its finished product. Medicube's one-week figures, Drunk Elephant's and Osmotics' four-week percentages, and Dr. Pickart's "Clinical Proven" are all given without a group size or a control.

Why the copper is rarely the main active

Only Dr. Pickart states an amount. In COSRX (24th of 28), Medicube (47th of 52) and Osmotics (22nd of 29) the copper is near the end of the list; in Anua it is one of four peptides after caffeine, ceramides and squalane. Acetyl Hexapeptide-8, adenosine and a vitamin K and retinol combination each have at least one published eye-area study in people1211; GHK-Cu has none. A copper peptide in an eye cream is a reason to read the rest of the label, not a result on its own.

Other peptides

Do other peptide eye creams have better evidence?

Somewhat better: two peptides have been tested around the eye in controlled human trials.

Argireline (Acetyl Hexapeptide-8): a placebo-controlled eye trial

In a 2013 randomised, placebo-controlled trial, 60 people (3:1 active to placebo) applied Argireline to periorbital wrinkles twice daily for 4 weeks; 48.9% of the active group showed overall improvement against 0% on placebo, and roughness on silicone skin replicas fell1. The trial was short and the abstract gives no concentration. The developer's earlier study reported a 10% emulsion reduced wrinkle depth by up to 30% in 30 days, but its clinical part was small and uncontrolled15. Acetyl Hexapeptide-8 is in the COSRX, Anua and Medicube eye creams.

Pal-KTTKS (Palmitoyl Pentapeptide-4)

In a 2005 split-face trial of 93 women over 12 weeks, 3 ppm Pal-KTTKS improved facial wrinkles against a control16; that was the whole face, not the eye area. Its eye-area data come from the 2009 trials below, where an eye cream containing it improved crow's-feet smoothness13. It is in the COSRX and Medicube eye creams.

Adenosine

In a study of 22 women with crow's feet, an adenosine cream used twice daily for 8 weeks improved wrinkles, elasticity and hydration, with no adverse effects, but there was no vehicle comparison2. Adenosine is in the COSRX, Anua and Medicube eye creams.

Eye cream or face cream

Does an eye cream work better than your face cream?

Not in the one study that compared them on crow's feet. In two double-blind, randomised split-face studies of 42 and 35 women aged 30 to 70, published in 2009, participants applied 0.5 g twice daily for 4 weeks of products sharing niacinamide, Pal-KT, Pal-KTTKS and carnosine: an SPF 30 day lotion, a night cream, an eye cream with added caffeine, and a retinyl propionate treatment13. In the first study, the day lotion, night cream and eye cream all improved crow's-feet smoothness against no treatment, but only the lotion and night cream improved one of the two roughness measures; pooled, all three improved both. The face products did at least as well as the matched eye cream.

The limits: the products were made by the study's sponsor, the comparison was untreated skin rather than a placebo cream, and 4 weeks is short. Still, there is no evidence that eye cream as a category works differently from a face formula. The real differences are texture, how much of an irritant (retinoid, acid, fragrance) it contains, and whether it has been tested near the eye.

Follow the label

Can I use my face serum around my eyes?

Follow the directions on your serum. The evidence suggests face formulas can improve crow's feet as well as eye creams13, and the Argireline and adenosine trials applied ordinary formats to the eye area12, but many brands tell you to keep their serums away from the eyes: COSRX's Blue Peptide serum says "avoiding the eye area", and a haruharu wonder serum says "avoiding the eye and mouth area". Osmotics tells you to keep its richer face cream away from the lid.

koppā's serum and cream are directed for the face and neck only, and the serum's directions say to keep it out of your eyes. Our balm stick is the only koppā product whose directions include the under-eye contour.

If a product's label allows the eye area, apply it on the orbital bone, the ridge you can feel around the eye, not on the lid margin or lash line; patch test first; and stop if it stings or turns red171819.

Safety

Can copper peptide eye creams irritate the eyelids?

They can, as any eye product can, though copper itself is rarely the cause. Allergy to copper is rare20. Eyelid skin, though, reacts easily: in a 10-year analysis of 1,215 patch-tested patients, 105 had eyelid dermatitis, of whom 43.8% had allergic contact dermatitis, 36.2% seborrhoeic dermatitis and 7.6% irritant dermatitis; the allergens included fragrances, metals, preservatives and several medicines17. In 203 people with eyelid dermatitis, a relevant allergic contact dermatitis was found in 74%, from cosmetics, metals and medications among others18. A 2024 meta-analysis of 65 studies and 21,793 patch-tested patients found atopic eyelid dermatitis in 27.5%19. The metals in these studies are mostly not copper.

The cosmetic safety panel assessed copper tripeptide-1 and its metal salts as used in cosmetics in 201821; we did not re-read its eye-irritation data for this page. The retinoid in four of these seven products is a more likely source of stinging, and Anua, Medicube and Dr. Pickart all advise starting every other day or gradually.

Ask a doctor or dermatologist first if you have eyelid eczema or a recurring rash around the eyes (stop new products and ask about patch testing), a known copper allergy, or if you are pregnant or breastfeeding: avoid the retinoid eye creams (Anua, Medicube, Cell Fusion C and Drunk Elephant) unless a clinician agrees. GHK-Cu itself has not been studied in pregnancy, which means it is unstudied, not that it is unsafe.

What koppā makes

Does koppā make a copper peptide eye cream?

No. koppā makes a 2% GHK-Cu serum (45 ml, US$75), a 0.5% GHK-Cu capsule cream (80 g, US$70) and a 0.5% GHK-Cu balm stick (20 g, US$45). The serum and cream are directed for the face and neck, not the eye area.

The balm stick is the only one with eye-area directions: use it sparingly on the under-eye contour, avoid the lash line and direct contact with the eyes, and do not tug the skin. It is a water-free moisturising balm, not an eye treatment. It states its GHK-Cu dose, which among the eye products here only Dr. Pickart also does, but 0.5% is a quarter of Dr. Pickart's 2%; it has no caffeine; and koppā reports testing the finished formula for hydration and ingredient stability, not around the eye. US shipping is US$3, free over US$100; returns within 30 days of delivery, unopened, seal intact. We compare balms in our GHK-Cu balm guide.

Fit

Who should look elsewhere?

A copper peptide eye cream suits you if you want a peptide-led eye product with or without a retinoid, mainly for fine lines and crow's feet, and you accept that the copper itself has no peer-reviewed eye-area trial.

Look elsewhere if you are mainly bothered by:

bags from fat or a tear-trough shadow: creams cannot change anatomy89; ask an oculoplastic or dermatologic surgeon about fillers or surgery;

brown, pigmented circles: copper peptides are not depigmenting, and topical options are borrowed from melasma treatment9; daily sunscreen, possibly a retinoid, and a dermatologist;

bluish, vascular circles: vitamin K with retinol had a partial effect in an open study11; caffeine eye products have only uncontrolled, manufacturer-run data12;

crow's feet you want treated medically: Argireline1, a retinoid product and daily SPF are the cream routes; neuromodulator injections are the medical one;

eyelid eczema or a recurrent rash: stop new products and get patch tested, since allergic contact dermatitis is the commonest cause in patch-tested patients1718.

Method in detail

Our method in detail

We compare disclosed formulas against ingredient research and any product-specific evidence the brand reports.

What we looked at / Why it matters
Check What we looked at Why it matters
Copper ingredient identity

Copper Tripeptide-1, Prezatide Copper Acetate, Bis(Tripeptide-1) Copper Acetate, or another copper compound.

The GHK-Cu research covers GHK-copper complexes; Copper Lysinate/Prolinate and Copper PCA are different ingredients.

Stated percentage

Whether the label gives a GHK-Cu percentage or milligrams.

Only one eye product here does; without it, position is the only clue.

Position in the ingredient list

Counted item by item from the seller's published list.

Order cannot give an unstated percentage, but it shows whether the copper is a major or minor ingredient.

Other actives

Retinoids, caffeine, adenosine and other peptides.

These often have more eye-area evidence than the copper, and retinoids change how you should start.

Fragrance

The brand's claim, read against the ingredient list.

Fragrance is a leading allergen in eyelid dermatitis17.

Price per ml or g

Dated list price divided by the stated size.

A consistent basis; we do not convert ounces of weight to millilitres.

Shipping and returns

The seller's own US shipping and returns pages, the same day.

The real cost and risk of trying an eye product that may sting.

Evidence level

Human, skin-sample and cadaver studies, and any brand-reported test of the finished product.

We say what was tested, by whom, and how many people took part.

Copper ingredient identity

What we looked at

Copper Tripeptide-1, Prezatide Copper Acetate, Bis(Tripeptide-1) Copper Acetate, or another copper compound.

Why it matters

The GHK-Cu research covers GHK-copper complexes; Copper Lysinate/Prolinate and Copper PCA are different ingredients.

Stated percentage

What we looked at

Whether the label gives a GHK-Cu percentage or milligrams.

Why it matters

Only one eye product here does; without it, position is the only clue.

Position in the ingredient list

What we looked at

Counted item by item from the seller's published list.

Why it matters

Order cannot give an unstated percentage, but it shows whether the copper is a major or minor ingredient.

Other actives

What we looked at

Retinoids, caffeine, adenosine and other peptides.

Why it matters

These often have more eye-area evidence than the copper, and retinoids change how you should start.

Fragrance

What we looked at

The brand's claim, read against the ingredient list.

Why it matters

Fragrance is a leading allergen in eyelid dermatitis17.

Price per ml or g

What we looked at

Dated list price divided by the stated size.

Why it matters

A consistent basis; we do not convert ounces of weight to millilitres.

Shipping and returns

What we looked at

The seller's own US shipping and returns pages, the same day.

Why it matters

The real cost and risk of trying an eye product that may sting.

Evidence level

What we looked at

Human, skin-sample and cadaver studies, and any brand-reported test of the finished product.

Why it matters

We say what was tested, by whom, and how many people took part.

Compare the seven eye creams See the balm stick, $45

Our "best for" labels describe the need each product suits, based on its disclosed formula. Product information comes from each seller's own pages on 4 November 2026; if a brand changes its formula or price, our figures will be out of date until our next check.

Around the eyes

How to apply an eye cream

The same rules apply whichever product you choose, and the product's own directions come first.

  1. 01

    Patch test first

    Try it on a small area for a few days before using it around both eyes, and stop if it stings or turns red.

  2. 02

    Stay on the orbital bone

    Use a small amount, such as a rice grain per eye as Osmotics advises, and tap it along the bone around the eye, not on the lid margin or lash line.

  3. 03

    Start a retinoid slowly

    If the product contains retinol or retinal, use it every other day at first, as Anua and Medicube advise, and do not add a second retinoid to the same area.

  4. 04

    Wear sunscreen in the morning

    Sun damage deepens crow's feet, and Drunk Elephant's directions say to always use a broad-spectrum sunscreen.

Compare the seven eye creams See the balm stick, $45
Koppā Face + Body Balm Stick, 20 g, with its lift-off cap and copper band: 0.5% GHK-Cu copper peptide balm with eight supporting peptides for targeted dry areas.
From koppā, with its limits

If you want copper peptide around the eyes from koppā, the balm stick is the one with under-eye directions.

It is not an eye cream. It is a water-free moisturising balm stating 0.5% GHK-Cu in a 20 g stick, and its directions say to use it sparingly on the under-eye contour, avoid the lash line and direct contact with the eyes, and not tug the skin. It has no caffeine and no eye-area test: koppā reports testing the finished formula for hydration and ingredient stability only. At 0.5% it states a quarter of Dr. Pickart's 2%. Our serum and cream are directed for the face and neck, not the eye area.

  • 0.5% GHK-Cu stated, 20 g stick
  • Under-eye contour only, away from the lash line
$45
koppā 0.5% GHK-Cu Copper Peptide Face + Body Balm Stick
See the balm stick, $45

FAQ

Questions about copper peptide eye creams

What is the best copper peptide eye cream?

For a stated GHK-Cu dose, Dr. Loren Pickart GHK Luxe Eye Cream: 2% (300 mg in 15 ml), with no retinoid, for experienced users who will build up slowly. For a cheap, gentle, retinoid-free option, COSRX Advanced Snail Peptide Eye Cream (US$28 for 25 ml); for retinol at the lowest price, Anua Retinol 0.1 Caffeine Revitalizing Eye Cream (US$22 at Ulta). Checked 4 November 2026; no GHK-Cu eye product has a peer-reviewed trial.

Do copper peptide eye creams work?

There is no peer-reviewed trial of any GHK-Cu eye product. One 2002 study reported that a GHK-Cu eye cream beat a placebo and a vitamin K eye cream on lines and skin thickness in 41 women over 12 weeks, but it was never published and is known only from a review by GHK's discoverer14. Other ingredients in these creams, such as Acetyl Hexapeptide-8, have controlled eye-area trials1.

Which copper peptide eye cream has the most GHK-Cu?

Dr. Loren Pickart GHK Luxe Eye Cream is the only eye cream we found that states a dose: 2%, given as 300 mg in 15 ml, with Copper Tripeptide-1 11th of 24 ingredients. COSRX, Anua, Medicube, Cell Fusion C, Osmotics and Drunk Elephant state no copper percentage.

Is under-eye skin really thinner?

Yes. The upper eyelid is the thinnest skin on the face in cadaver studies34 and in a 2025 ultrasound study of 45 living adults, at a median of 573.5 µm against 1,907 µm at the nasal tip5. The skin below the eyes also failed to thicken with age the way other facial sites did, in a study of 40 women6.

Can I put my copper peptide serum under my eyes?

Follow the label. Many face serums, including koppā's, are directed for the face and neck and say to keep them out of the eyes. A 2009 trial found face products improved crow's feet at least as well as a matched eye cream13, so if your serum's label allows it, stay on the orbital bone, away from the lash line, and patch test first.

Does koppā make an eye cream?

No. koppā's balm stick (0.5% GHK-Cu, 20 g) is the only koppā product with under-eye directions: sparingly, on the under-eye contour, away from the lash line. It is a moisturising balm, not an eye cream, and has not been tested around the eye. koppā's serum and cream are directed for the face and neck.

Will copper peptides fix dark circles?

Unlikely on their own. Dark circles come from pigment, visible blood vessels, thin skin, puffiness and shadowing, often in combination8910, and copper peptides are not depigmenting. No copper peptide eye product reports a controlled dark-circle result.

Can a copper peptide eye cream reduce puffiness?

Puffiness from fat bags under the eye is anatomical, and no cream changes it8. Caffeine is the usual ingredient for puffiness in eye creams, and its eye-area evidence is an uncontrolled, manufacturer-funded 12-week study of 40 people12.

Is Copper Tripeptide-1 the same as prezatide copper acetate?

Copper Tripeptide-1, Prezatide Copper Acetate (Osmotics) and Bis(Tripeptide-1) Copper Acetate (Drunk Elephant) are all GHK-copper complexes under different names. Copper Lysinate/Prolinate and Copper PCA are different copper compounds: Allies of Skin's eye cream uses copper lysinate/prolinate, and the Osmotics Under Eye Rejuvenator lists no copper at all.

Are peptide eye creams proven for crow's feet?

Partly. Argireline (Acetyl Hexapeptide-8) beat placebo on periorbital wrinkles over 4 weeks in a 60-person randomised trial1, and an eye cream with Pal-KTTKS improved crow's-feet smoothness in 4-week split-face trials, though face products did as well13. Both trials were short.

Can copper peptides irritate the eye area?

Copper allergy is rare20, but eyelid skin reacts easily, and allergic contact dermatitis was the leading diagnosis in patch-tested eyelid dermatitis, at 43.8% of 105 patients in one 10-year analysis17. Dr. Pickart's own directions advise every-other-day use and warn against sensitive skin, so patch test any eye product first.

Should I use a copper peptide eye cream with retinol?

Four of these seven already contain a retinoid: Anua, Medicube and Drunk Elephant (retinol) and Cell Fusion C (retinal). Start those every other day, as Anua and Medicube advise, and do not add a second retinoid to the same area. If you want copper without a retinoid, COSRX and Dr. Pickart list none.

How long before a copper peptide eye cream shows results?

Peptide trials around the eye measured change at 4 weeks113, and the unpublished GHK-Cu eye-cream report used 12 weeks14. Give a new eye product at least a month before judging it, and stop sooner if it irritates.

What is the cheapest copper peptide eye cream?

Anua Retinol 0.1 Caffeine Revitalizing Eye Cream, US$22 for 1.05 oz at Ulta (about US$0.74 per g), and COSRX Advanced Snail Peptide Eye Cream, US$28 for 25 ml (US$1.12 per ml), checked 4 November 2026. Neither states a copper percentage.

Is this comparison sponsored?

No. No brand paid to be included, and links to other brands earn us nothing. koppā makes copper peptide skincare but no eye cream, so no koppā product is ranked here; every figure links to the seller's own page so you can check it.

Sources

Scientific references

References are numbered as cited. Where a study was done on cadavers, run by a manufacturer, had no control group, or is known only from a review, the text says so. Product facts come from each brand's own pages, linked on each product.

  1. 1.Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J. The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. Am J Clin Dermatol. 2013;14(2):147-153. Read the paper
  2. 2.Kang G, Tu TNT, Kim S, et al. Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration. Int J Cosmet Sci. 2018;40(2):199-206. Read the paper
  3. 3.Ha RY, Nojima K, Adams WP Jr, Brown SA. Analysis of facial skin thickness: defining the relative thickness index. Plast Reconstr Surg. 2005;115(6):1769-1773. (Cadaver study, n=3.) Read the paper
  4. 4.Chopra K, Calva D, Sosin M, et al. A comprehensive examination of topographic thickness of skin in the human face. Aesthet Surg J. 2015;35(8):1007-1013. (Cadaver study, 10 heads.) Read the paper
  5. 5.Korzekwa S, Matusz K, Kukulski M, et al. Quantitative analysis of the human face skin thickness: a high-frequency ultrasound study. J Clin Med. 2025;14(23):8401. Read the paper
  6. 6.Pellacani G, Seidenari S. Variations in facial skin thickness and echogenicity with site and age. Acta Derm Venereol. 1999;79(5):366-369. Read the paper
  7. 7.Hostynek JJ, Dreher F, Maibach HI. Human skin penetration of a copper tripeptide in vitro as a function of skin layer. Inflamm Res. 2011;60(1):79-86. (Skin samples.) Read the paper
  8. 8.Vrcek I, Ozgur O, Nakra T. Infraorbital dark circles: a review of the pathogenesis, evaluation and treatment. J Cutan Aesthet Surg. 2016;9(2):65-72. (Review.) Read the paper
  9. 9.Sarkar R, Ranjan R, Garg S, et al. Periorbital hyperpigmentation: a comprehensive review. J Clin Aesthet Dermatol. 2016;9(1):49-55. (Review.) Read the paper
  10. 10.Goberdhan LT, Schneider K, Pellacani G, et al. Pathophysiologic aspects of dark eye circles in various Fitzpatrick skin types. Clin Cosmet Investig Dermatol. 2026;19:605666. (Observational, n=42; industry-funded.) Read the paper
  11. 11.Mitsuishi T, Shimoda T, Mitsui Y, Kuriyama Y, Kawana S. The effects of topical application of phytonadione, retinol and vitamins C and E on infraorbital dark circles and wrinkles of the lower eyelids. J Cosmet Dermatol. 2004;3(2):73-75. (Open-label.) Read the paper
  12. 12.Rajabi-Estarabadi A, Hartman CL, Iglesia S, et al. Effectiveness and tolerance of multicorrective topical treatment for infraorbital dark circles and puffiness. J Cosmet Dermatol. 2024;23(2):486-495. (Open-label; manufacturer-funded.) Read the paper
  13. 13.Kaczvinsky JR, Griffiths CE, Schnicker MS, Li J. Efficacy of anti-aging products for periorbital wrinkles as measured by 3-D imaging. J Cosmet Dermatol. 2009;8(3):228-233. Read the paper
  14. 14.Pickart L, Vasquez-Soltero JM, Margolina A. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. Biomed Res Int. 2015;2015:648108. (Review; reports the unpublished 2002 Leyden et al. eye-cream study.) Read the paper
  15. 15.Blanes-Mira C, Clemente J, Jodas G, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. (Developer study.) Read the paper
  16. 16.Robinson LR, Fitzgerald NC, Doughty DG, Dawes NC, Berge CA, Bissett DL. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci. 2005;27(3):155-160. Read the paper
  17. 17.Amin KA, Belsito DV. The aetiology of eyelid dermatitis: a 10-year retrospective analysis. Contact Dermatitis. 2006;55(5):280-285. Read the paper
  18. 18.Guin JD. Eyelid dermatitis: experience in 203 cases. J Am Acad Dermatol. 2002;47(5):755-765. Read the paper
  19. 19.Borzova E, Snarskaya E, Bratkovskaya A. Eyelid dermatitis in patch-tested adult patients: a systematic review with a meta-analysis. Sci Rep. 2024;14(1):18791. Read the paper
  20. 20.Fage SW, Faurschou A, Thyssen JP. Copper hypersensitivity. Contact Dermatitis. 2014;71(4):191-201. Read the paper
  21. 21.Johnson W Jr, Bergfeld WF, Belsito DV, et al. Safety assessment of Tripeptide-1, Hexapeptide-12, their metal salts and fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 as used in cosmetics. Int J Toxicol. 2018;37(3 Suppl):90S-102S. Read the paper